Thursday, October 4, 2007
| October 4, 200718:15 (UTC+1) | |||
| Hamburg | 3 – 1 | Litex Lovech | HSH Nordbank Arena, HamburgReferee: Paul Allaerts |
| José Paolo Guerrero 40’José Paolo Guerrero 52’Rafael van der Vaart 71′ | Hamburg win 4-1 on aggregate | Robert Popov 38′ |
| October 4, 200719:00 (UTC+1) | |||
| Vålerenga | 2 – 2 | Austria Vienna | Ullevaal Stadion, OsloReferee: Radek Mat?jek |
| Freddy Dos Santos 51’Thomas Holm 87′ | Austria Vienna win 4-2 on aggregate | Saniel Kuljic 22’Milenko A?imovi? 90+1′ |
| October 4, 200719:00(UTC+1) | |||
| Häcken | 1 – 3 | Spartak Moscow | Rambergsvallen, GothenburgReferee: Sten Kaldma |
| Jonas Henriksson 84′ | Spartak Moscow win 8-1 on aggregate | Yegor Titov 7’Nikita Bazhenov 80’Artem Dzyuba 90+1′ |
| October 4, 200720:00(UTC) | |||
| Blackburn Rovers | 2 – 1 | Larissa | Ewood Park, BlackburnReferee: Claudio Circhetta |
| Matthew Derbyshire (pen) 45+2’Stephen Warnock 54′ | Larissa win 3-2 on aggregate | Cleyton 17′ |
| October 4, 200720:30(UTC+1) | |||
| Red Bull Salzburg | 1 – 0 | AEK Athens | Wals Siezenheim Stadium, SalzburgReferee: Paolo Tagliavento |
| Vratislav Lokvenc 20′ | AEK win 3-1 on aggregate |
| October 4, 200721:00(UTC+1) | |||
| Girondins de Bordeaux | 1 – 1 | Tampere United | Stade Chaban-Delmas, BordeauxReferee: Nikolay Ivanov |
| Marouane Chamakh 49′ | Bordeaux win 4-3 on aggregate | Antti Ojanperä 50′ |
| October 4, 200721:15(UTC) | |||
| União Leiria | 3 – 2 | Bayer Leverkusen | Estádio Dr. Magalhães Pessoa, LeiriaReferee: Costas Kapitanis |
| Cadu 3’João Paulo 21’Laranjeiro 90′ | Bayer Leverkusen win 4-5 on aggregate | Michal Papadopulos 10’Stefan Kiessling 87′ |
| October 4, 200720:45 (UTC+2) | |||
| Rapid Vienna | 0 – 1 | Anderlecht | Gerhard Hanappi Stadium, ViennaReferee: Nicola Rizzoli |
| Anderlecht win 2-1 on aggregate | Hassan Ahmed 22′ |
| October 4, 200721:45 (UTC+3) | |||
| FC Metalist Kharkiv | 2 – 3 | Everton | Gerhard Hanappi Stadium, ViennaReferee: Nicola Rizzoli |
| Edmar 21’Hicham Mahdoufi 52′ | Everton win 4-3 on aggregate | Jolean Lescott 48’James McFadden 72’Victor Anichebe 88′ |